THE GREATEST GUIDE TO IS METHADONE AN OPIATE OR AN OPIOID

[61] Like a lot of other cardiotoxic drugs, methadone blocks the hERG K+ channel. The two enantiomers of methadone inhibit hERG channels with diverse potency. Dextromethadone, that is less potent being an opioid, is much more potent at blocking the hERG channel with an IC50 of ~twelve μM. Levomethadone incorporates a lower affinity, with an IC50 o